No association between GRM3 and Japanese methamphetamine induced psychosis

Tomoko Tsunoka, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

研究成果: Article

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Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls). Methods: We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). Results: We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis. Conclusion: Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine-induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.

元の言語English
ページ(範囲)160-162
ページ数3
ジャーナルCurrent Neuropharmacology
9
発行部数1
DOI
出版物ステータスPublished - 30-03-2011

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Methamphetamine
Psychotic Disorders
Linkage Disequilibrium
Schizophrenia
Genes
Paranoid Schizophrenia
Ethics Committees
Informed Consent
Synaptic Transmission
Substance-Related Disorders
Single Nucleotide Polymorphism
Psychiatry
Case-Control Studies
Glutamic Acid
Medicine
Mutation
Health
Brain
Population
metabotropic glutamate receptor 3

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

これを引用

Tsunoka, Tomoko ; Kishi, Taro ; Ikeda, Masashi ; Kitajima, Tsuyoshi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Okochi, Tomo ; Okumura, Takenori ; Inada, Toshiya ; Ujike, Hiroshi ; Yamada, Mitsuhiko ; Uchimura, Naohisa ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Iwata, Nakao. / No association between GRM3 and Japanese methamphetamine induced psychosis. :: Current Neuropharmacology. 2011 ; 巻 9, 番号 1. pp. 160-162.
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abstract = "Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls). Methods: We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). Results: We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis. Conclusion: Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine-induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.",
author = "Tomoko Tsunoka and Taro Kishi and Masashi Ikeda and Tsuyoshi Kitajima and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Tomo Okochi and Takenori Okumura and Toshiya Inada and Hiroshi Ujike and Mitsuhiko Yamada and Naohisa Uchimura and Ichiro Sora and Masaomi Iyo and Norio Ozaki and Nakao Iwata",
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Tsunoka, T, Kishi, T, Ikeda, M, Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Kawashima, K, Okochi, T, Okumura, T, Inada, T, Ujike, H, Yamada, M, Uchimura, N, Sora, I, Iyo, M, Ozaki, N & Iwata, N 2011, 'No association between GRM3 and Japanese methamphetamine induced psychosis', Current Neuropharmacology, 巻. 9, 番号 1, pp. 160-162. https://doi.org/10.2174/157015911795017001

No association between GRM3 and Japanese methamphetamine induced psychosis. / Tsunoka, Tomoko; Kishi, Taro; Ikeda, Masashi; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Okochi, Tomo; Okumura, Takenori; Inada, Toshiya; Ujike, Hiroshi; Yamada, Mitsuhiko; Uchimura, Naohisa; Sora, Ichiro; Iyo, Masaomi; Ozaki, Norio; Iwata, Nakao.

:: Current Neuropharmacology, 巻 9, 番号 1, 30.03.2011, p. 160-162.

研究成果: Article

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T1 - No association between GRM3 and Japanese methamphetamine induced psychosis

AU - Tsunoka, Tomoko

AU - Kishi, Taro

AU - Ikeda, Masashi

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Okumura, Takenori

AU - Inada, Toshiya

AU - Ujike, Hiroshi

AU - Yamada, Mitsuhiko

AU - Uchimura, Naohisa

AU - Sora, Ichiro

AU - Iyo, Masaomi

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2011/3/30

Y1 - 2011/3/30

N2 - Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls). Methods: We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). Results: We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis. Conclusion: Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine-induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.

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