No association between GRM3 and Japanese methamphetamine induced psychosis

Tomoko Tsunoka, Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Toshiya Inada, Hiroshi Ujike, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

研究成果: Article

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Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls). Methods: We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). Results: We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis. Conclusion: Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine-induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.

元の言語English
ページ(範囲)160-162
ページ数3
ジャーナルCurrent Neuropharmacology
9
発行部数1
DOI
出版物ステータスPublished - 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

フィンガープリント No association between GRM3 and Japanese methamphetamine induced psychosis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Tsunoka, T., Kishi, T., Ikeda, M., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Okochi, T., Okumura, T., Inada, T., Ujike, H., Yamada, M., Uchimura, N., Sora, I., Iyo, M., Ozaki, N., & Iwata, N. (2011). No association between GRM3 and Japanese methamphetamine induced psychosis. Current Neuropharmacology, 9(1), 160-162. https://doi.org/10.2174/157015911795017001