No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a Japanese population

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Tatsuyo Suzuki, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Norio Ozaki, Nakao Iwata

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Altered dopamine D2 receptor (D2R) is hypothesized to be a susceptibility factor for major psychosis. Recent studies showed that a new intracellular protein, prostate apoptosis response 4 (Par-4), plays a critical role in D2R signaling. We conducted a genetic association analysis between Par-4 gene (PAWR) and schizophrenia and mood disorders in a Japanese population (schizophrenia: 556 cases, bipolar disorder (BP): 150 cases, major depressive disorder (MDD): 312 cases and 466 controls). Applying the recommended 'gene-based' association analysis, we selected five tagging SNPs in PAWR from the HapMap database. No significant association was obtained found with schizophrenia or MDD or BP. We found a significant association of one tagging SNP with BP in a genotype-wise analysis (P = 0.0396); however, this might be resulted from type I error due to multiple testing (P = 0.158 after SNPSpD correction). Considering the size of our sample and strategy, our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population.

本文言語English
ページ(範囲)531-534
ページ数4
ジャーナルAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
147
4
DOI
出版ステータスPublished - 05-06-2008

All Science Journal Classification (ASJC) codes

  • 遺伝学(臨床)
  • 精神医学および精神衛生
  • 細胞および分子神経科学

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