No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Branko Aleksic; Masashi Ikeda; Ryoko Ishihara; Shinichi Saito; Toshiya Inada; Nakao Iwata; Norio Ozaki

doi:10.1007/s10038-008-0318-7

No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

Branko Aleksic
, Masashi Ikeda
, Ryoko Ishihara
, Shinichi Saito
, Toshiya Inada
, Nakao Iwata
, Norio Ozaki

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

抄録

PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.

本文言語	英語
ページ（範囲）	863-866
ページ数	4
ジャーナル	Journal of Human Genetics
巻	53
号	9
DOI	https://doi.org/10.1007/s10038-008-0318-7
出版ステータス	出版済み - 09-2008

All Science Journal Classification (ASJC) codes

遺伝学
遺伝学（臨床）

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10.1007/s10038-008-0318-7

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abstract = "PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.",

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AU - Ikeda, Masashi

AU - Ishihara, Ryoko

AU - Saito, Shinichi

AU - Inada, Toshiya

AU - Iwata, Nakao

AU - Ozaki, Norio

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AB - PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.

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No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population

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All Science Journal Classification (ASJC) codes

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