No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder: A collaborative study by the Japanese genetics initiative for drug abuse

N. Iwata, T. Inada, M. Harano, T. Komiyama, M. Yamada, Y. Sekine, M. Iyo, I. Sora, H. Ujike, N. Ozaki

研究成果: Article査読

12 被引用数 (Scopus)

抄録

In the central nervous system, tissue-plasminogen activator (t-PA)/ plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to be a major contributor to the substance abuse liability and/or the development of MAP psychosis.

本文言語English
ページ(範囲)34-38
ページ数5
ジャーナルAnnals of the New York Academy of Sciences
1025
DOI
出版ステータスPublished - 2004

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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