No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients

Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Toshiya Inada, Norio Ozaki

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.

本文言語English
ページ(範囲)127-130
ページ数4
ジャーナルSchizophrenia Research
78
2-3
DOI
出版ステータスPublished - 15-10-2005

All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生
  • 生物学的精神医学

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