No association of serotonin transporter gene (SLC6A4) with schizophrenia and bipolar disorder in Japanese patients: Association analysis based on linkage disequilibrium

M. Ikeda, N. Iwata, T. Suzuki, T. Kitajima, Y. Yamanouchi, Y. Kinoshita, N. Ozaki

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Serotonin transporter gene (SLC6A4) is one of the most promising candidate genes for psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BP). Two functional polymorphisms, 5HTTLPR and 5HTTVNTR, have been a focus for genetic association analyses; however, no conclusive results have been obtained. We conducted, 1) a mutation search of SLC6A4, 2) LD mapping to select 'tagging' markers (10 SNPs and 5HTTVNTR, while 5HTTLPR was treated as an independent marker because of its allelic form), and 3) association analysis of these 'tagging' markers and independent markers (5HTTLPR and Asn605Lys) with SCZ and BP in Japanese patients. In this mutation search, a nonsynonymous SNP, Asn605Lys, was detected. No associations of 'tagging' markers and independent markers with such conditions were found. These results indicate that SLC6A4 might not play a major role in SCZ and BP in Japanese patients, a finding that agrees with both the common disease-common variant hypothesis and common disease-rare variant hypothesis.

本文言語English
ページ(範囲)899-905
ページ数7
ジャーナルJournal of Neural Transmission
113
7
DOI
出版ステータスPublished - 07-2006

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学

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