Previous studies show that genetic haplotype within the neuregulin 1 gene (NRG1) increase the risk of developing schizophrenia. The authors described a negative replication that a haplotype of NRG1 did not associate with schizophrenia. Of 607 Japanese schizophrenic patients and 515 controls, the estimated frequency of the core at-risk haplotype had no difference between patients (4.5%) and controls (4.3%). The data suggests that NRG1 haplotype is unlikely to be associated with increased risk of schrizophrenia.
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