Novel transcript nort is a downstream target gene of the Notch signaling pathway in zebrafish

Makiko Tsutsumi, Motoyuki Itoh

研究成果: Article査読

10 被引用数 (Scopus)


The Notch signaling pathway plays important roles in the regulation of diverse developmental processes. Although many Notch-signal target genes with different specificities have been identified, their regulation and functions are not fully understood. Here, we conducted a microarray screen to search for novel downstream target genes of the Notch pathway in zebrafish. From the screen, we isolated nort (Notch-regulated transcript) as a transcript whose expression was reduced by the inhibition of Notch signaling. The expression level of nort increased when Notch signaling was activated. nort was expressed in hypoblast cells and the developing nervous system. We found its expression pattern to be similar to that of her4, but it showed some differences, at least in the anterior and posterior neural plate at the 3-somite stage. The nort transcript did not contain any long open-reading frame (ORF) of more than 300 nt, and its ORF-encoded sequence showed no significant homology with the proteins in databases. However, nort has one SPS (suppressor of hairless paired binding site) in its 5′-flanking region. These data suggest that nort is a putative noncoding RNA regulated by Notch signaling.

ジャーナルGene Expression Patterns
出版ステータスPublished - 02-01-2007

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学
  • 発生生物学


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