TY - JOUR
T1 - Nucleotide sequences that distinguish Oka vaccine from parental Oka and other Varicella-Zoster virus isolates
AU - Argaw, Takele
AU - Cohen, Jeffrey I.
AU - Klutch, Michael
AU - Lekstrom, Kristen
AU - Yoshikawa, Tetsushi
AU - Asano, Yoshizo
AU - Krause, Philip R.
N1 - Funding Information:
Grant support: National Vaccine Program via an appointment to the postgraduate research participation program at the Center for Biologics Evaluation and Research that was administered by the Oak Ridge Institute for Science and Education through the interagency agreement between the US Department of Energy and the Food and Drug Administration (FDA).
PY - 2000
Y1 - 2000
N2 - The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.
AB - The sequences of ~34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.
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U2 - 10.1086/315335
DO - 10.1086/315335
M3 - Article
C2 - 10720545
AN - SCOPUS:0034117538
SN - 0022-1899
VL - 181
SP - 1153
EP - 1157
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
