Odorant suppression of delayed rectifier potassium current in newt olfactory receptor cells

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Effects of odorants on a delayed rectifier potassium current (I(K)) in newt olfactory receptor cells (ORCs) were investigated using the whole-cell version of the patch-clamp technique. Under voltage clamp, odorants (amyl acetate, limonene and acetophenone) reversibly suppressed I(K) without shifting its I-V curve. An amyl acetate puff completely suppressed I(K) induced by the first step pulse of repetitive depolarizations, suggesting that binding of an odorant molecule to the open channel is not required to block the channel. Although it is known that odorants suppress Na+ and Ca2+ currents (I(Na), I(Ca)) by shifting their inactivation curves to a negative voltage, odorants did not shift the inactivation curve of I(K) significantly. This suggests that odorants suppress I(K) without changing its voltage dependence. Therefore, the blocking mechanisms by odorants of I(K) in ORCs are different from those of I(Na) and I(Ca).

本文言語English
ページ(範囲)45-48
ページ数4
ジャーナルNeuroscience Letters
269
1
DOI
出版ステータスPublished - 02-07-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

フィンガープリント

「Odorant suppression of delayed rectifier potassium current in newt olfactory receptor cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル