Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma

Gaku Takano, Shinichi Esaki, Fumi Goshima, Atsushi Enomoto, Yoshimi Hatano, Haruka Ozaki, Takahiro Watanabe, Yoshitaka Sato, Daisuke Kawakita, Shingo Murakami, Takayuki Murata, Yukihiro Nishiyama, Shinichi Iwasaki, Hiroshi Kimura

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Immune responses can enhance anti-tumor capacity of viruses; therefore, full investigation of oncolytic virotherapy requires use of non-immunodeficient mice. Since no commercial cell lines are available, we established a murine model for oral carcinoma and evaluated oncolytic activity of HF10, naturally attenuated herpes simplex virus, in vitro and in vivo.

本文言語English
ページ(範囲)220-227
ページ数8
ジャーナルMolecular Therapy - Oncolytics
20
DOI
出版ステータスPublished - 26-03-2021

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 腫瘍学
  • 癌研究
  • 薬理学(医学)

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