Opioid κ receptors correlate with the development of conditioned suppression of motility in mice

Toshitaka Nabeshima, Hiroyuki Kamei, Tsutomu Kameyama

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Mice exhibited a marked suppression of motility (conditioned suppression) when placed in the same environment in which they had previously received an electric footshock. The conditioned suppression of motility was potentiated by U-69,593, a selective κ (non-μ) agonist. This effect of U-69,593 was antagonized by MR-2266, a κ antagonist. Additionally, in contrast to U-69,593, MR-2266 alone attenuated the conditioned suppression of motility. These results suggest that the activation of κ receptors may be responsible for the development of conditioned suppression of motility.

本文言語English
ページ(範囲)129-133
ページ数5
ジャーナルEuropean Journal of Pharmacology
152
1-2
DOI
出版ステータスPublished - 26-07-1988
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 薬理学

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