Optimal Timing of Cabazitaxel Introduction for Japanese Patients with Metastatic Castration-resistant Prostate Cancer

Toshiki Ito, Kent Kanao, Kiyoshi Takahara, Ryosuke Ando, Takahiro Yasui, Ryoichi Shiroki, Makoto Sumitomo, Hideaki Miyake

研究成果: Article

抄録

Background/Aim: Limited information is available to help physicians decide when to introduce cabazitaxel for metastatic castration-resistant prostate cancer (mCRPC) patients. The objective of this study was to assess the optimal timing of cabazitaxel introduction. Patients and Methods: The clinical outcomes of 66 mCRPC patients receiving cabazitaxel following failure of docetaxel were retrospectively analyzed. Results: Among the parameters possibly affecting the timing of cabazitaxel introduction, only an increased prostate-specific antigen (PSA) value from the diagnosis of CRPC had a significant impact on overall survival (OS) after the introduction of cabazitaxel. Furthermore, there was a significant correlation between the increased PSA value from the diagnosis of CRPC and the baseline PSA value at cabazitaxel introduction. Multivariate analysis showed that only the baseline PSA value at cabazitaxel introduction is an independent predictor of OS. Conclusion: A comparatively low PSA value could be an alternative index suggesting the optimal timing for cabazitaxel introduction.

元の言語English
ページ(範囲)3089-3094
ページ数6
ジャーナルAnticancer research
39
発行部数6
DOI
出版物ステータスPublished - 01-01-2019

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Castration
Prostatic Neoplasms
Prostate-Specific Antigen
docetaxel
Survival
cabazitaxel
Multivariate Analysis
Physicians

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ito, Toshiki ; Kanao, Kent ; Takahara, Kiyoshi ; Ando, Ryosuke ; Yasui, Takahiro ; Shiroki, Ryoichi ; Sumitomo, Makoto ; Miyake, Hideaki. / Optimal Timing of Cabazitaxel Introduction for Japanese Patients with Metastatic Castration-resistant Prostate Cancer. :: Anticancer research. 2019 ; 巻 39, 番号 6. pp. 3089-3094.
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abstract = "Background/Aim: Limited information is available to help physicians decide when to introduce cabazitaxel for metastatic castration-resistant prostate cancer (mCRPC) patients. The objective of this study was to assess the optimal timing of cabazitaxel introduction. Patients and Methods: The clinical outcomes of 66 mCRPC patients receiving cabazitaxel following failure of docetaxel were retrospectively analyzed. Results: Among the parameters possibly affecting the timing of cabazitaxel introduction, only an increased prostate-specific antigen (PSA) value from the diagnosis of CRPC had a significant impact on overall survival (OS) after the introduction of cabazitaxel. Furthermore, there was a significant correlation between the increased PSA value from the diagnosis of CRPC and the baseline PSA value at cabazitaxel introduction. Multivariate analysis showed that only the baseline PSA value at cabazitaxel introduction is an independent predictor of OS. Conclusion: A comparatively low PSA value could be an alternative index suggesting the optimal timing for cabazitaxel introduction.",
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Optimal Timing of Cabazitaxel Introduction for Japanese Patients with Metastatic Castration-resistant Prostate Cancer. / Ito, Toshiki; Kanao, Kent; Takahara, Kiyoshi; Ando, Ryosuke; Yasui, Takahiro; Shiroki, Ryoichi; Sumitomo, Makoto; Miyake, Hideaki.

:: Anticancer research, 巻 39, 番号 6, 01.01.2019, p. 3089-3094.

研究成果: Article

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AU - Yasui, Takahiro

AU - Shiroki, Ryoichi

AU - Sumitomo, Makoto

AU - Miyake, Hideaki

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