Oral administration of idebenone, a stimulator of NGF synthesis, recovers reduced NGF content in aged rat brain

Atsumi Nitta, Takaaki Hasegawa, Toshitaka Nabeshima

研究成果: Article査読

28 被引用数 (Scopus)

抄録

The relationship between nerve growth factor (NGF) and senile dementia of the Alzheimer type is of interest. We demonstrate here that the oral administration of idebenone, a stimulator of NGF synthesis in vitro, produced recovery of reduced NGF content in aged rat brain. Twenty-one-day successive administration of idebenone produced significant recovery of reduced NGF content in the frontal cortex and parietal cortex of aged rats. These results suggest that NGF content in the brain is low in aged rats and that oral administration of idebenone leads to a recovery of this reduction.

本文言語English
ページ(範囲)219-222
ページ数4
ジャーナルNeuroscience Letters
163
2
DOI
出版ステータスPublished - 12-12-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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