Oropharyngeal shedding of Epstein-Barr virus in the absence of circulating B cells

Susan E. Hoover, Junichi Kawada, Wyndham Wilson, Jeffrey I. Cohen

研究成果: ジャーナルへの寄稿学術論文査読

21 被引用数 (Scopus)

抄録

Infection with Epstein-Barr virus (EBV) results in lifelong infection of B cells in the peripheral blood and in episodic shedding of virus from the oropharynx. We monitored patients treated with rituximab (anti-CD20 monoclonal antibody) and found that several had both no detectable B cells and no EBV in the blood but shed EBV from the throat. Although some models postulate that EBV traffics from the B cells in the blood to the throat, where it is subsequently shed, our findings indicate that circulating EBV in B cells is not necessary for the virus to persist in, and to be shed from, the oropharynx.

本文言語英語
ページ(範囲)318-323
ページ数6
ジャーナルJournal of Infectious Diseases
198
3
DOI
出版ステータス出版済み - 01-08-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 感染症

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