Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno, Shusuke Nakazawa, Naoki Yamamoto, Masanori Shinzato, Shigeo Nagashima, Kumiko Tanaka, Jun Sasaki, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

研究成果: Article

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Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

元の言語English
ページ(範囲)2423-2427
ページ数5
ジャーナルInfection and Immunity
74
発行部数4
DOI
出版物ステータスPublished - 01-04-2006

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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    Maeno, Y., Nakazawa, S., Yamamoto, N., Shinzato, M., Nagashima, S., Tanaka, K., Sasaki, J., Rittling, S. R., Denhardt, D. T., Uede, T., & Taniguchi, K. (2006). Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Infection and Immunity, 74(4), 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006