Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno; Shusuke Nakazawa; Naoki Yamamoto; Masanori Shinzato; Shigeo Nagashima; Kumiko Tanaka; Jun Sasaki; Susan R. Rittling; David T. Denhardt; Toshimitsu Uede; Koki Taniguchi

doi:10.1128/IAI.74.4.2423-2427.2006

Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice

Yoshimasa Maeno
, Shusuke Nakazawa
, Naoki Yamamoto
, Masanori Shinzato
, Shigeo Nagashima
, Kumiko Tanaka
, Jun Sasaki
, Susan R. Rittling
, David T. Denhardt
, Toshimitsu Uede
, Koki Taniguchi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

20 被引用数 (Scopus)

抄録

Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.

本文言語	英語
ページ（範囲）	2423-2427
ページ数	5
ジャーナル	Infection and Immunity
巻	74
号	4
DOI	https://doi.org/10.1128/IAI.74.4.2423-2427.2006
出版ステータス	出版済み - 04-2006

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この成果は、次の持続可能な開発目標に貢献しています

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All Science Journal Classification (ASJC) codes

寄生虫科
微生物学
免疫学
感染症

文献へのアクセス

10.1128/IAI.74.4.2423-2427.2006

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引用スタイル

Maeno, Y., Nakazawa, S., Yamamoto, N., Shinzato, M., Nagashima, S., Tanaka, K., Sasaki, J., Rittling, S. R., Denhardt, D. T., Uede, T., & Taniguchi, K. (2006). Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Infection and Immunity, 74(4), 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006

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abstract = "Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.",

author = "Yoshimasa Maeno and Shusuke Nakazawa and Naoki Yamamoto and Masanori Shinzato and Shigeo Nagashima and Kumiko Tanaka and Jun Sasaki and Rittling, \{Susan R.\} and Denhardt, \{David T.\} and Toshimitsu Uede and Koki Taniguchi",

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Maeno, Y, Nakazawa, S, Yamamoto, N, Shinzato, M, Nagashima, S, Tanaka, K, Sasaki, J, Rittling, SR, Denhardt, DT, Uede, T & Taniguchi, K 2006, 'Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice', Infection and Immunity, vol. 74, no. 4, pp. 2423-2427. https://doi.org/10.1128/IAI.74.4.2423-2427.2006

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AU - Maeno, Yoshimasa

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