Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae

Dóra Szabó, Fernanda Silveira, Andrea M. Hujer, Robert A. Bonomo, Kristine M. Hujer, Jane W. Marsh, Christopher R. Bethel, Yohei Doi, Kathleen Deeley, David L. Paterson

研究成果: Article査読

71 被引用数 (Scopus)

抄録

We investigated ertapenem-susceptible and -resistant extended-spectrum β-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.

本文言語English
ページ(範囲)2833-2835
ページ数3
ジャーナルAntimicrobial agents and chemotherapy
50
8
DOI
出版ステータスPublished - 08-2006

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

フィンガープリント 「Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル