Overexpression of Interleukin-1α Suppresses Liver Metastasis of Lymphoma: Implications for Antitumor Effects of CD8+ T-cells

Kazuhiko Udagawa, Yasuo Niki, Toshiyuki Kikuchi, Yusuke Fukuhara, Yuki Takeda, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura

研究成果: ジャーナルへの寄稿学術論文査読

3 被引用数 (Scopus)

抄録

Interleukin (IL)-1 plays a key role in carcinogenesis, tumor progression, and metastasis. Although IL-1 may enhance the expansion of CD8+ T-cells, the pathological contribution of IL-1-activated CD8+ T-cells to tumor metastasis remains unclear. This study used a liver metastasis model of the EL4 T-cell lymphoma cells transplanted into human IL (hIL)-1α conditional transgenic (hIL-1α cTg) mice. Overproduction of hIL-1α suppressed both macroscopic and histological liver metastasis of EL4 T-cell lymphoma. The hIL-1α-induced inflammatory state increased the number of CD8+ T-cells both within and around metastatic tumors. Moreover, larger numbers of CD8+ T-cells showed greater infiltration of liver blood vessels in hIL-1α cTg mice than in control wild-type mice. Terminal deoxynucleotidyl transferase dUTP nick-end labeling staining of liver tissue from hIL-1α cTg mice indicated increased apoptosis of cells in the tumor. Localization of apoptosis cells resembled that of CD8+ T-cells. In addition, cytotoxicity assay showed that CD8+ T-cell counts from tumor-bearing hIL-1α cTg mice correlated with cytotoxicity against EL4.

本文言語英語
ページ(範囲)245-255
ページ数11
ジャーナルJournal of Histochemistry and Cytochemistry
69
4
DOI
出版ステータス出版済み - 04-2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 解剖学
  • 組織学

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