Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors

Mika Sugiura; Masato Nagaoka; Hikaru Yabuuchi; Toshihiro Akaike

doi:10.1016/j.bbrc.2007.06.109

Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors

Mika Sugiura
, Masato Nagaoka
, Hikaru Yabuuchi
, Toshihiro Akaike

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

抄録

Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.

本文言語	英語
ページ（範囲）	741-745
ページ数	5
ジャーナル	Biochemical and Biophysical Research Communications
巻	360
号	4
DOI	https://doi.org/10.1016/j.bbrc.2007.06.109
出版ステータス	出版済み - 07-09-2007

All Science Journal Classification (ASJC) codes

生物理学
生化学
分子生物学
細胞生物学

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10.1016/j.bbrc.2007.06.109

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title = "Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors",

abstract = "Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.",

keywords = "Differentiation, ES cells, MCT8 (slc16a2), Neural cells, Slc family, Transporter",

author = "Mika Sugiura and Masato Nagaoka and Hikaru Yabuuchi and Toshihiro Akaike",

note = "Funding Information: We thank Prof. Hitoshi Niwa of the RIKEN Center for Developmental Biology for his generous gifts of ES cell lines (EB3 cells and MG1.19 cells) and episomal expression vector pHPCAG. This work was supported by a Grant of the 21st Century COE Program and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. ",

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T1 - Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors

AU - Sugiura, Mika

AU - Nagaoka, Masato

AU - Yabuuchi, Hikaru

AU - Akaike, Toshihiro

N1 - Funding Information: We thank Prof. Hitoshi Niwa of the RIKEN Center for Developmental Biology for his generous gifts of ES cell lines (EB3 cells and MG1.19 cells) and episomal expression vector pHPCAG. This work was supported by a Grant of the 21st Century COE Program and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2007/9/7

Y1 - 2007/9/7

N2 - Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.

AB - Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.

KW - Differentiation

KW - ES cells

KW - MCT8 (slc16a2)

KW - Neural cells

KW - Slc family

KW - Transporter

UR - https://www.scopus.com/pages/publications/34447542833

UR - https://www.scopus.com/pages/publications/34447542833#tab=citedBy

U2 - 10.1016/j.bbrc.2007.06.109

DO - 10.1016/j.bbrc.2007.06.109

M3 - Article

C2 - 17624308

AN - SCOPUS:34447542833

SN - 0006-291X

VL - 360

SP - 741

EP - 745

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors

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