Overexpression of piccolo C2A domain induces depression-like behavior in mice

Yoko Furukawa-Hibi, Atsumi Nitta, Hidefumi Fukumitsu, Hitomi Somiya, Shoei Furukawa, Toshitaka Nabeshima, Kiyofumi Yamada

研究成果: Article

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Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.

元の言語English
ページ(範囲)1177-1181
ページ数5
ジャーナルNeuroreport
21
発行部数18
DOI
出版物ステータスPublished - 29-12-2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Furukawa-Hibi, Y., Nitta, A., Fukumitsu, H., Somiya, H., Furukawa, S., Nabeshima, T., & Yamada, K. (2010). Overexpression of piccolo C2A domain induces depression-like behavior in mice. Neuroreport, 21(18), 1177-1181. https://doi.org/10.1097/WNR.0b013e3283411685