Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours

Y. Nakagawa, H. Morikawa, I. Hirata, M. Shiozaki, A. Matsumoto, K. Maemura, T. Nishikawa, M. Niki, N. Tanigawa, M. Ikegami, K. Katsu, Y. Akao

研究成果: Article査読

62 被引用数 (Scopus)

抄録

The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours.

本文言語English
ページ(範囲)914-917
ページ数4
ジャーナルBritish Journal of Cancer
80
5-6
DOI
出版ステータスPublished - 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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