OXA-23 and OXA-40 producing carbapenem-resistant Acinetobacter baumannii in Central Illinois

Janak Koirala, Isha Tyagi, Lohitha Guntupalli, Sameena Koirala, Udita Chapagain, Christopher Quarshie, Sami Akram, Vidya Sundareshan, Sajan Koirala, Jerry Lawhorn, Yohei Doi, Michael Olson

研究成果: Article

抜粋

We reviewed susceptibility of 840 A. baumannii complex isolates at two academic medical centers and explored their mechanism of carbapenem resistance. Carbapenem resistance rates among A. baumannii increased from <5% before 2005 to 55% in 2011 and declined thereafter. We subjected 86 isolates for further antibiotic susceptibility testing using E-test, screened for MBL and carbapenemase production, and performed PCR for blaOXA genes. Statistical analyses included correlation of resistance genes with susceptibility. Sixty-one isolates were non-susceptible to carbapenems (MIC >2 μg/mL). Phenotypic screening showed carbapenemase production in 50 isolates, but none was positive for MBL. Among carbapenem non-susceptible isolates, the CHDL (group D carbapenemase) encoding genes blaOXA-23 (52%) and blaOXA-40 (28%) were the most frequent genes. In conclusion, carbapenem resistance rates in A. baumannii peaked in 2011 and have since declined in our region. Carbapenem resistance among A. baumannii was primarily associated with production of acquired CHDLs including OXA-23 and OXA-40.

元の言語English
記事番号114999
ジャーナルDiagnostic Microbiology and Infectious Disease
97
発行部数1
DOI
出版物ステータスPublished - 05-2020

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

これを引用

Koirala, J., Tyagi, I., Guntupalli, L., Koirala, S., Chapagain, U., Quarshie, C., Akram, S., Sundareshan, V., Koirala, S., Lawhorn, J., Doi, Y., & Olson, M. (2020). OXA-23 and OXA-40 producing carbapenem-resistant Acinetobacter baumannii in Central Illinois. Diagnostic Microbiology and Infectious Disease, 97(1), [114999]. https://doi.org/10.1016/j.diagmicrobio.2020.114999