TY - JOUR
T1 - Oxygen-enhanced magnetic resonance imaging versus computed tomography
T2 - Multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease
AU - Ohno, Yoshiharu
AU - Iwasawa, Tae
AU - Joom, Beom Seo
AU - Koyama, Hisanobu
AU - Takahashi, Hiroshi
AU - Oh, Yeon Mok
AU - Nishimura, Yoshihiro
AU - Sugimura, Kazuro
PY - 2008/5/15
Y1 - 2008/5/15
N2 - Rationale: Oxygen-enhanced magnetic resonance imaging (MRI) has been proposed as a useful tool for assessing regional morphological and functional changes in chronic obstructive pulmonary disease (COPD). Objectives: To prospectively and directly compare the efficacy of O2-enhanced MRI and quantitative computed tomography (CT) for smoking-related pulmonary functional loss assessment and clinical stage classification of smoking-related COPD. Methods: One hundred sixty smokers were classified into four age- and gender-matched groups by using the GOLD criteria for smokers: Smokers without COPD (n = 40), Mild COPD (n = 40), Moderate COPD (n = 40), and Severe or Very Severe COPD (n = 40). All smokers underwent O2-enhanced MRI, multidetector-row CT, and pulmonary function test. Mean relative enhancement ratio on O2-enhanced MRI and CT-based functional lung volume (FLV) on quantitative CT were calculated. To compare the efficacy of O 2-enhanced MRI and quantitative CT for pulmonary functional loss assessment, both indexes were correlated with pulmonary functional parameters. To determine the efficacy of two methods for clinical stage classification, the four clinical groups' mean relative enhancement ratio and CT-based FLV were statistically compared. Measurements and Main Results: Correlations of both indexes with pulmonary functional parameters were significant (P < 0.0001). Pulmonary functional parameters and mean relative enhancement ratio for the four clinical groups showed significant differences (P < 0.05). CT-based FLVs of smokers without COPD and mild COPD were significantly different from those for moderate COPD and severe or very severe COPD (P < 0.05). Conclusions: O 2-enhanced MRI is effective for pulmonary functional loss assessment and clinical stage classification of smoking-related COPD and quantitative CT.
AB - Rationale: Oxygen-enhanced magnetic resonance imaging (MRI) has been proposed as a useful tool for assessing regional morphological and functional changes in chronic obstructive pulmonary disease (COPD). Objectives: To prospectively and directly compare the efficacy of O2-enhanced MRI and quantitative computed tomography (CT) for smoking-related pulmonary functional loss assessment and clinical stage classification of smoking-related COPD. Methods: One hundred sixty smokers were classified into four age- and gender-matched groups by using the GOLD criteria for smokers: Smokers without COPD (n = 40), Mild COPD (n = 40), Moderate COPD (n = 40), and Severe or Very Severe COPD (n = 40). All smokers underwent O2-enhanced MRI, multidetector-row CT, and pulmonary function test. Mean relative enhancement ratio on O2-enhanced MRI and CT-based functional lung volume (FLV) on quantitative CT were calculated. To compare the efficacy of O 2-enhanced MRI and quantitative CT for pulmonary functional loss assessment, both indexes were correlated with pulmonary functional parameters. To determine the efficacy of two methods for clinical stage classification, the four clinical groups' mean relative enhancement ratio and CT-based FLV were statistically compared. Measurements and Main Results: Correlations of both indexes with pulmonary functional parameters were significant (P < 0.0001). Pulmonary functional parameters and mean relative enhancement ratio for the four clinical groups showed significant differences (P < 0.05). CT-based FLVs of smokers without COPD and mild COPD were significantly different from those for moderate COPD and severe or very severe COPD (P < 0.05). Conclusions: O 2-enhanced MRI is effective for pulmonary functional loss assessment and clinical stage classification of smoking-related COPD and quantitative CT.
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U2 - 10.1164/rccm.200709-1322OC
DO - 10.1164/rccm.200709-1322OC
M3 - Article
C2 - 18276941
AN - SCOPUS:43849097396
SN - 1073-449X
VL - 177
SP - 1095
EP - 1102
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 10
ER -