Oxygen-Enhanced MR Imaging for Lung: Basics and Clinical Applications

Y. Ohno, H. Koyama, H. Y. Lee, Y. Kishida, S. Seki, T. Yoshikawa, K. Sugimura

研究成果: 書籍/レポート タイプへの寄稿

1 被引用数 (Scopus)

抄録

Oxygen-enhanced magnetic resonance (MR) imaging has been advocated since 1996 as a technique for evaluation of regional ventilation using molecular oxygen as the contrast agent. Molecular oxygen, which contains two unpaired electrons and is weakly paramagnetic, can provide not only regional ventilation, but also oxygen transfer (i.e., diffusion of oxygen from alveoli to capillary bed) and related information for oxygen-enhanced MR imaging.Many investigators have successfully used oxygen-enhanced MR imaging for patients with pulmonary diseases such as chronic obstructive pulmonary disease, asthma, interstitial lung disease, pulmonary vascular diseases, and lung cancer in a clinical setting, and demonstrated the physiological significance of oxygen enhancement.In this review article, we discuss (1) respiratory physiology relevant for oxygen-enhanced MR imaging; (2) theory of oxygen enhancement; (3) oxygen-enhanced MR imaging sequence design; (4) basic study of oxygen-enhanced MR imaging for animal models and humans; (5) clinical studies of oxygen-enhanced MR imaging; and (6) advantages and disadvantages of oxygen-enhanced MR imaging compared with those of hyperpolarized noble gas MR imaging.

本文言語英語
ホスト出版物のタイトルHyperpolarized and Inert Gas MRI
ホスト出版物のサブタイトルFrom Technology to Application in Research and Medicine
出版社Elsevier Inc.
ページ239-250
ページ数12
ISBN(電子版)9780128037041
ISBN(印刷版)9780128036754
DOI
出版ステータス出版済み - 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学一般
  • 健康専門職一般

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