P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a P-selectin ligand and Partly as an E-selectin ligand

Hajime Tomita, Yohei Iwata, Fumihide Ogawa, Kazuhiro Komura, Kazuhiro Shimizu, Ayumi Yoshizaki, Toshihide Hara, Eiji Muroi, Koichi Yanaba, Sangjae Bae, Motoi Takenaka, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Cell adhesion molecules are critical to wound healing through leukocyte recruitment. Although P-selectin glycoprotein ligand-1 (PSGL-1) regulates leukocyte rolling by binding P-selectin, but also binding E- and L-selectins with lower affinity, little is known about a role of PSGL-1 in wound healing. To clarify a role of PSGL-1 and its interaction with E- and P-selectins in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient (PSGL-1 /) mice in comparison with E-selectin /, P-selectin /, and P-selectin / mice treated with an anti-E-selectin antibody. PSGL-1 deficiency inhibited early wound healing, which was accompanied by decreased inflammatory cell infiltration and growth factor expression. By contrast, E-selectin deficiency did not affect wound healing. In general, the inhibitory effect of PSGL-1 deficiency on wound healing was similar to that of P-selectin deficiency either alone or with E-selectin blockade. However, early granulation tissue formation, late angiogenesis, and early infiltration of neutrophils and macrophages in PSGL-1 / mice were inhibited beyond the inhibition in P-selectin / mice, but to a similar level of inhibition in P-selectin / mice with E-selectin blockade. These results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells.

本文言語English
ページ(範囲)2059-2067
ページ数9
ジャーナルJournal of Investigative Dermatology
129
8
DOI
出版ステータスPublished - 08-2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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