Paired related homeobox 1 is associated with the invasive properties of Glioblastoma cells

Mai Sugiyama, Hitoki Hasegawa, Satoko Ito, Kazuya Sugiyama, Masao Maeda, Kosuke Aoki, Toshihiko Wakabayashi, Michinari Hamaguchi, Atsushi Natsume, Takeshi Senga

研究成果: ジャーナルへの寄稿学術論文査読

21 被引用数 (Scopus)

抄録

Glioblastoma is a highly proliferative and invasive tumor. Despite extensive efforts to develop treatments for glioblastoma, the currently available therapies have only limited effects. To develop novel strategies for glioblastoma treatment, it is crucial to elucidate the molecular mechanisms that promote the invasive properties of glioblastoma. In the present study, we showed that the paired related homeobox 1 (PRRX1) is associated with glioblastoma cell invasion. The depletion of PRRX1 suppressed the invasion and neurosphere formation of glioblastoma cells. Conversely, the exogenous expression of PRRX1 promoted invasion. The Notch signaling pathway, which is an evolutionarily conserved pathway that is essential for developmental processes, plays an important role in the tumorigenesis of glioblastoma. The expression of PRRX1 induced the activation of Notch signaling, and the inhibition of Notch signaling suppressed PRRX1-mediated cell invasion. Our results indicate that activation of Notch signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion.

本文言語英語
ページ(範囲)1123-1130
ページ数8
ジャーナルOncology reports
33
3
DOI
出版ステータス出版済み - 01-03-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

フィンガープリント

「Paired related homeobox 1 is associated with the invasive properties of Glioblastoma cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル