Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor

Eun Joo Shin, Wan Kyunn Whang, Sungun Kim, Jae Hyung Bach, Jin Man Kim, Xuan Khanh Thi Nguyen, Thuy Ty Lan Nguyen, Bae Dong Jung, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Parishin C, a major component of Gastrodia elata B LUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35 S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.

本文言語English
ページ(範囲)404-408
ページ数5
ジャーナルJournal of Pharmacological Sciences
113
4
DOI
出版ステータスPublished - 2010

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 薬理学

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