Patients that have undergone hemodialysis exhibit lower amyloid deposition in the brain: Evidence supporting a therapeutic strategy for Alzheimer's disease by removal of blood amyloid

Kazuyoshi Sakai, Takao Senda, Ryuji Hata, Makoto Kuroda, Midori Hasegawa, Masao Kato, Masato Abe, Kazunori Kawaguchi, Shigeru Nakai, Yoshiyuki Hiki, Yukio Yuzawa, Nobuya Kitaguchi

研究成果: Article査読

30 被引用数 (Scopus)

抄録

As a proof of concept that removal of blood amyloid-β (Aβ) can reduce Aβ deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes Aβ from the blood, were histochemically analyzed; postmortem brain sections were stained with anti-Aβ antibodies. Brains from patients who had undergone HD had significantly fewer senile plaques than those of patient who had not undergone HD.∗This significant difference was also confirmed by silver staining.∗Our findings suggest that removal of blood Aβ by hemodialysis results in lower accumulation of Aβ in the brain.

本文言語English
ページ(範囲)997-1002
ページ数6
ジャーナルJournal of Alzheimer's Disease
51
4
DOI
出版ステータスPublished - 12-04-2016

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 臨床心理学
  • 老年医学
  • 精神医学および精神衛生

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