Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels

Mohamed Hamed Hussein, Takashi Hashimoto, Ghada Abdel-Hamid Daoud, Takazumi Kato, Masahito Hibi, Hirokazu Tomishige, Fujio Hara, Tatsuya Suzuki, Yoko Nakajima, Tatenobu Goto, Tetsuya Ito, Ineko Kato, Atsushi Sugioka, Hajime Togari

研究成果: Article

5 引用 (Scopus)

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Background: ABO-incompatible liver transplantation (LTx) is becoming more common in response to the paucity of liver allografts. Several studies have expressed concern about the effect of ABO compatibility on graft survival. Purpose: To evaluate the differences in serum cytokine levels between ABO-incompatible (ABO-i) and ABO-compatible (ABO-c; includes ABO-compatible and identical) pediatric LTx recipients during regular outpatient follow-up. Note that, in the field of organ transplantation, transplants are categorized as incompatible, compatible or identical; accordingly, these are the terms we use in the paper. Materials and methods: A clinical outpatient study measuring serum transforming growth factor (TGF)-β1, interferon (IFN)-γ, interleukin (IL)-2 and IL-10 in 43 living related liver transplantation (LRLT) recipients, of whom 36 received ABO-c LRLT (34 were ABO-identical and 2 were non-identical) and 7 ABO-i LRLT. Serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase and bilirubin were measured as part of the patients' regular follow-up visits. Results: There were no differences between the ABO-c and ABO-i groups in terms of recipient's age [mean 12.6 vs. 11.1 years (y)], post-LTx duration (mean 7.3 vs. 7.3 y), donor's age (mean 35.5 vs. 34.6 y), body weight (28.9 ± 2.9 vs. 27.9 ± 6.9 kg), or gender (19 female and 17 male vs. 4 female and 3 male). Serum TGF-β1, IFN-γ and IL-2 were significantly higher in the ABO-i group than in the ABO-c group. IL-10, however, did not differ between the two groups. There was a tendency toward higher γGTP levels in the ABO-i group, but this difference did not reach significance. Conclusion: ABO-incompatible LRLTx patients have higher serum TGF-β1, IFN-γ and IL-2 levels as measured at regular outpatient visits. As a result, they face a higher risk of T-helper 1 cell polarization, which could make graft rejection more likely.

元の言語English
ページ(範囲)263-268
ページ数6
ジャーナルPediatric Surgery International
27
発行部数3
DOI
出版物ステータスPublished - 01-03-2011
外部発表Yes

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Transforming Growth Factors
Liver Transplantation
Interferons
Interleukin-2
Pediatrics
Serum
Outpatients
Interleukin-10
Th1 Cells
gamma-Glutamyltransferase
Graft Rejection
Organ Transplantation
Graft Survival
Aspartate Aminotransferases
Guanosine Triphosphate
Alanine Transaminase
L-Lactate Dehydrogenase
Bilirubin
Allografts
Alkaline Phosphatase

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

これを引用

Hussein, Mohamed Hamed ; Hashimoto, Takashi ; Abdel-Hamid Daoud, Ghada ; Kato, Takazumi ; Hibi, Masahito ; Tomishige, Hirokazu ; Hara, Fujio ; Suzuki, Tatsuya ; Nakajima, Yoko ; Goto, Tatenobu ; Ito, Tetsuya ; Kato, Ineko ; Sugioka, Atsushi ; Togari, Hajime. / Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels. :: Pediatric Surgery International. 2011 ; 巻 27, 番号 3. pp. 263-268.
@article{d01e54d91d984a4b96ed685b70dc86f4,
title = "Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels",
abstract = "Background: ABO-incompatible liver transplantation (LTx) is becoming more common in response to the paucity of liver allografts. Several studies have expressed concern about the effect of ABO compatibility on graft survival. Purpose: To evaluate the differences in serum cytokine levels between ABO-incompatible (ABO-i) and ABO-compatible (ABO-c; includes ABO-compatible and identical) pediatric LTx recipients during regular outpatient follow-up. Note that, in the field of organ transplantation, transplants are categorized as incompatible, compatible or identical; accordingly, these are the terms we use in the paper. Materials and methods: A clinical outpatient study measuring serum transforming growth factor (TGF)-β1, interferon (IFN)-γ, interleukin (IL)-2 and IL-10 in 43 living related liver transplantation (LRLT) recipients, of whom 36 received ABO-c LRLT (34 were ABO-identical and 2 were non-identical) and 7 ABO-i LRLT. Serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase and bilirubin were measured as part of the patients' regular follow-up visits. Results: There were no differences between the ABO-c and ABO-i groups in terms of recipient's age [mean 12.6 vs. 11.1 years (y)], post-LTx duration (mean 7.3 vs. 7.3 y), donor's age (mean 35.5 vs. 34.6 y), body weight (28.9 ± 2.9 vs. 27.9 ± 6.9 kg), or gender (19 female and 17 male vs. 4 female and 3 male). Serum TGF-β1, IFN-γ and IL-2 were significantly higher in the ABO-i group than in the ABO-c group. IL-10, however, did not differ between the two groups. There was a tendency toward higher γGTP levels in the ABO-i group, but this difference did not reach significance. Conclusion: ABO-incompatible LRLTx patients have higher serum TGF-β1, IFN-γ and IL-2 levels as measured at regular outpatient visits. As a result, they face a higher risk of T-helper 1 cell polarization, which could make graft rejection more likely.",
author = "Hussein, {Mohamed Hamed} and Takashi Hashimoto and {Abdel-Hamid Daoud}, Ghada and Takazumi Kato and Masahito Hibi and Hirokazu Tomishige and Fujio Hara and Tatsuya Suzuki and Yoko Nakajima and Tatenobu Goto and Tetsuya Ito and Ineko Kato and Atsushi Sugioka and Hajime Togari",
year = "2011",
month = "3",
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doi = "10.1007/s00383-010-2784-1",
language = "English",
volume = "27",
pages = "263--268",
journal = "Pediatric Surgery International",
issn = "0179-0358",
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number = "3",

}

Hussein, MH, Hashimoto, T, Abdel-Hamid Daoud, G, Kato, T, Hibi, M, Tomishige, H, Hara, F, Suzuki, T, Nakajima, Y, Goto, T, Ito, T, Kato, I, Sugioka, A & Togari, H 2011, 'Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels', Pediatric Surgery International, 巻. 27, 番号 3, pp. 263-268. https://doi.org/10.1007/s00383-010-2784-1

Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels. / Hussein, Mohamed Hamed; Hashimoto, Takashi; Abdel-Hamid Daoud, Ghada; Kato, Takazumi; Hibi, Masahito; Tomishige, Hirokazu; Hara, Fujio; Suzuki, Tatsuya; Nakajima, Yoko; Goto, Tatenobu; Ito, Tetsuya; Kato, Ineko; Sugioka, Atsushi; Togari, Hajime.

:: Pediatric Surgery International, 巻 27, 番号 3, 01.03.2011, p. 263-268.

研究成果: Article

TY - JOUR

T1 - Pediatric patients receiving ABO-incompatible living related liver transplantation exhibit higher serum transforming growth factor-β1, interferon-γ and interleukin-2 levels

AU - Hussein, Mohamed Hamed

AU - Hashimoto, Takashi

AU - Abdel-Hamid Daoud, Ghada

AU - Kato, Takazumi

AU - Hibi, Masahito

AU - Tomishige, Hirokazu

AU - Hara, Fujio

AU - Suzuki, Tatsuya

AU - Nakajima, Yoko

AU - Goto, Tatenobu

AU - Ito, Tetsuya

AU - Kato, Ineko

AU - Sugioka, Atsushi

AU - Togari, Hajime

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Background: ABO-incompatible liver transplantation (LTx) is becoming more common in response to the paucity of liver allografts. Several studies have expressed concern about the effect of ABO compatibility on graft survival. Purpose: To evaluate the differences in serum cytokine levels between ABO-incompatible (ABO-i) and ABO-compatible (ABO-c; includes ABO-compatible and identical) pediatric LTx recipients during regular outpatient follow-up. Note that, in the field of organ transplantation, transplants are categorized as incompatible, compatible or identical; accordingly, these are the terms we use in the paper. Materials and methods: A clinical outpatient study measuring serum transforming growth factor (TGF)-β1, interferon (IFN)-γ, interleukin (IL)-2 and IL-10 in 43 living related liver transplantation (LRLT) recipients, of whom 36 received ABO-c LRLT (34 were ABO-identical and 2 were non-identical) and 7 ABO-i LRLT. Serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase and bilirubin were measured as part of the patients' regular follow-up visits. Results: There were no differences between the ABO-c and ABO-i groups in terms of recipient's age [mean 12.6 vs. 11.1 years (y)], post-LTx duration (mean 7.3 vs. 7.3 y), donor's age (mean 35.5 vs. 34.6 y), body weight (28.9 ± 2.9 vs. 27.9 ± 6.9 kg), or gender (19 female and 17 male vs. 4 female and 3 male). Serum TGF-β1, IFN-γ and IL-2 were significantly higher in the ABO-i group than in the ABO-c group. IL-10, however, did not differ between the two groups. There was a tendency toward higher γGTP levels in the ABO-i group, but this difference did not reach significance. Conclusion: ABO-incompatible LRLTx patients have higher serum TGF-β1, IFN-γ and IL-2 levels as measured at regular outpatient visits. As a result, they face a higher risk of T-helper 1 cell polarization, which could make graft rejection more likely.

AB - Background: ABO-incompatible liver transplantation (LTx) is becoming more common in response to the paucity of liver allografts. Several studies have expressed concern about the effect of ABO compatibility on graft survival. Purpose: To evaluate the differences in serum cytokine levels between ABO-incompatible (ABO-i) and ABO-compatible (ABO-c; includes ABO-compatible and identical) pediatric LTx recipients during regular outpatient follow-up. Note that, in the field of organ transplantation, transplants are categorized as incompatible, compatible or identical; accordingly, these are the terms we use in the paper. Materials and methods: A clinical outpatient study measuring serum transforming growth factor (TGF)-β1, interferon (IFN)-γ, interleukin (IL)-2 and IL-10 in 43 living related liver transplantation (LRLT) recipients, of whom 36 received ABO-c LRLT (34 were ABO-identical and 2 were non-identical) and 7 ABO-i LRLT. Serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase and bilirubin were measured as part of the patients' regular follow-up visits. Results: There were no differences between the ABO-c and ABO-i groups in terms of recipient's age [mean 12.6 vs. 11.1 years (y)], post-LTx duration (mean 7.3 vs. 7.3 y), donor's age (mean 35.5 vs. 34.6 y), body weight (28.9 ± 2.9 vs. 27.9 ± 6.9 kg), or gender (19 female and 17 male vs. 4 female and 3 male). Serum TGF-β1, IFN-γ and IL-2 were significantly higher in the ABO-i group than in the ABO-c group. IL-10, however, did not differ between the two groups. There was a tendency toward higher γGTP levels in the ABO-i group, but this difference did not reach significance. Conclusion: ABO-incompatible LRLTx patients have higher serum TGF-β1, IFN-γ and IL-2 levels as measured at regular outpatient visits. As a result, they face a higher risk of T-helper 1 cell polarization, which could make graft rejection more likely.

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