Perioperative intensive insulin therapy using an artificial endocrine pancreas with closed-loop glycemic control system: The effects of no hypoglycemia

Kazuhiro Hanazaki, Hiroyuki Kitagawa, Tomoaki Yatabe, Masaya Munekage, Ken Dabanaka, Yuka Takezaki, Yuuki Tsukamoto, Takuji Asano, Yoshihiko Kinoshita, Tsutomu Namikawa

研究成果: Article査読

24 被引用数 (Scopus)

抄録

BACKGROUND: We examined whether perioperative intensive insulin therapy (IIT) using an artificial pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia in surgical patients. METHODS: Between 2006 and 2012, perioperative glycemic control using an AP was performed in 427 patients undergoing general surgery. A total of 305 patients undergoing IIT using an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study. Data were collected prospectively and were reviewed or analyzed retrospectively. RESULTS: No patients had hypoglycemia. Perioperative mean blood glucose level and achievement rates in target blood glucose range of 80 to 110 mg/dL were 100.5 ± 11.9 mg/dL and 88.1% ± 16.0%, respectively. For the 3 primary operative methods, including hepatic, pancreatic, and esophageal resections, there were no significant differences in glycemic control stability between the types of surgery. CONCLUSION: Perioperative IIT using an AP with a closed-loop glycemic control system can be used to prevent hypoglycemia and maintain stable glycemic control with less variability of blood glucose concentration.

本文言語English
ページ(範囲)935-941
ページ数7
ジャーナルAmerican Journal of Surgery
207
6
DOI
出版ステータスPublished - 06-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Surgery

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