Peripheral lipopolysaccharide administration affects the olfactory dopamine system in mice

Akira Ota, Keiji Mori, Yoko S. Kaneko, Akira Nakashima, Ikuko Nagatsu, Toshiharu Nagatsu

研究成果: Conference contribution

7 被引用数 (Scopus)


Peripheral administration of lipopolysaccharide (LPS) in an amount that produces acute stress has been found to affect the catecholamine systems in the brain. Acute peripheral LPS administration activated norepinephrine (NE) metabolism in the locus ceruleus (LC). Approximately 40% of murine LC neurons project to the olfactory bulb (OB) and the anterior olfactory nucleus (AON). Thus, we investigated the effects of a single intra-peritoneal (i.p.) LPS injection on catecholamine biosynthesis in the OB and AON in 8-week-old C3H/HeN male mice. In the AON, the content of dopamine (DA), but not that of NE, was highly increased 6 h after LPS injection. In the OB, the contents of DA and NE did not change; but within 2 h after a single i.p. LPS injection, the mRNA levels of IκB, TNF-α, and TNF-α receptor type 1 were significantly enhanced. Almost all TNF-α-immunoreactive cells in the OB of the LPS-injected mice were located in the granule cell layer, and unexpectedly, they were not microglia but astroglia. The number of TUNEL-positive cells identified exclusively in the granule cell layer was significantly increased at 24 h after LPS injection. Therefore, our data suggest that astroglia activated by peripherally injected LPS may release TNF-α, which may trigger apoptosis in the granule cell layer in the OB. The increase in DA content in the AON and the production of TNF-α and apoptotic cells in the OB by acute peripheral LPS administration are not likely to be related.

ホスト出版物のタイトルStress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms
出版社Blackwell Publishing Inc.
出版ステータスPublished - 12-2008


名前Annals of the New York Academy of Sciences

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学


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