Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Ikuko Sato, Hiroshi Arima, Noriyuki Ozaki, Nobuaki Ozaki, Minemori Watanabe, Motomitsu Goto, Hiroshi Shimizu, Masayuki Hayashi, Ryouichi Banno, Hiroshi Nagasaki, Yutaka Oiso

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.

本文言語English
ページ(範囲)4857-4864
ページ数8
ジャーナルFEBS Letters
581
25
DOI
出版ステータスPublished - 16-10-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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