Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Ikuko Sato; Hiroshi Arima; Noriyuki Ozaki; Nobuaki Ozaki; Minemori Watanabe; Motomitsu Goto; Hiroshi Shimizu; Masayuki Hayashi; Ryouichi Banno; Hiroshi Nagasaki; Yutaka Oiso

doi:10.1016/j.febslet.2007.09.011

Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Ikuko Sato
, Hiroshi Arima
, Noriyuki Ozaki
, Nobuaki Ozaki
, Minemori Watanabe
, Motomitsu Goto
, Hiroshi Shimizu
, Masayuki Hayashi
, Ryouichi Banno
, Hiroshi Nagasaki
, Yutaka Oiso

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

28 被引用数 (Scopus)

抄録

Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABA_B agonists could be a new therapeutic reagent for obesity.

本文言語	英語
ページ（範囲）	4857-4864
ページ数	8
ジャーナル	FEBS Letters
巻	581
号	25
DOI	https://doi.org/10.1016/j.febslet.2007.09.011
出版ステータス	出版済み - 16-10-2007
外部発表	はい

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All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/j.febslet.2007.09.011

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title = "Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice",

abstract = "Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.",

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author = "Ikuko Sato and Hiroshi Arima and Noriyuki Ozaki and Nobuaki Ozaki and Minemori Watanabe and Motomitsu Goto and Hiroshi Shimizu and Masayuki Hayashi and Ryouichi Banno and Hiroshi Nagasaki and Yutaka Oiso",

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AU - Sato, Ikuko

AU - Arima, Hiroshi

AU - Ozaki, Noriyuki

AU - Ozaki, Nobuaki

AU - Watanabe, Minemori

AU - Goto, Motomitsu

AU - Shimizu, Hiroshi

AU - Hayashi, Masayuki

AU - Banno, Ryouichi

AU - Nagasaki, Hiroshi

AU - Oiso, Yutaka

PY - 2007/10/16

Y1 - 2007/10/16

N2 - Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.

AB - Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.

KW - GABA agonists

KW - Hypothalamus

KW - Neuropeptide Y

KW - Obesity

KW - Pro-opiomelanocortin

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Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

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UN SDG

All Science Journal Classification (ASJC) codes

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