Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients

Akiho Sawai, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Susumu Toda, Isao Ito, Ryohei Hattori, Yoshihisa Matsukawa, Momokazu Gotoh, Yoshifumi Takei, Yukio Yuzawa, Seiichi Matsuo

研究成果: Article

13 引用 (Scopus)

抄録

Background. High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability.Methods. Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)-positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis.Results. Pre-dialysis uraemic peritoneum showed infiltration by CD68-positive macrophages, and mast cells, as compared with controls. Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). However, baseline peritoneal permeability was not correlated with infiltration by mast cells, B cells, T cells, neutrophils, serum C-reactive protein or other clinical factors. On multiple linear regression analysis, the number of CD68-positive macrophages in peritoneum was an independent predictor for baseline peritoneal permeability (P = 0.009).Conclusions. Peritoneal macrophage infiltration is predominant in uraemic patients and is an important factor in predicting baseline peritoneal permeability.

元の言語English
ページ(範囲)2322-2332
ページ数11
ジャーナルNephrology Dialysis Transplantation
26
発行部数7
DOI
出版物ステータスPublished - 01-07-2011
外部発表Yes

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Peritoneal Macrophages
Peritoneal Dialysis
Permeability
Peritoneum
Macrophages
Dialysis Solutions
Mast Cells
Endothelium
Blood Vessels
Dialysis
Linear Models
Interleukin-6
Creatinine
Neutrophils
B-Lymphocytes
Regression Analysis
Chymases
Inflammation
T-Lymphocytes
Biopsy

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

これを引用

Sawai, Akiho ; Ito, Yasuhiko ; Mizuno, Masashi ; Suzuki, Yasuhiro ; Toda, Susumu ; Ito, Isao ; Hattori, Ryohei ; Matsukawa, Yoshihisa ; Gotoh, Momokazu ; Takei, Yoshifumi ; Yuzawa, Yukio ; Matsuo, Seiichi. / Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. :: Nephrology Dialysis Transplantation. 2011 ; 巻 26, 番号 7. pp. 2322-2332.
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title = "Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients",
abstract = "Background. High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability.Methods. Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)-positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis.Results. Pre-dialysis uraemic peritoneum showed infiltration by CD68-positive macrophages, and mast cells, as compared with controls. Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). However, baseline peritoneal permeability was not correlated with infiltration by mast cells, B cells, T cells, neutrophils, serum C-reactive protein or other clinical factors. On multiple linear regression analysis, the number of CD68-positive macrophages in peritoneum was an independent predictor for baseline peritoneal permeability (P = 0.009).Conclusions. Peritoneal macrophage infiltration is predominant in uraemic patients and is an important factor in predicting baseline peritoneal permeability.",
author = "Akiho Sawai and Yasuhiko Ito and Masashi Mizuno and Yasuhiro Suzuki and Susumu Toda and Isao Ito and Ryohei Hattori and Yoshihisa Matsukawa and Momokazu Gotoh and Yoshifumi Takei and Yukio Yuzawa and Seiichi Matsuo",
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Sawai, A, Ito, Y, Mizuno, M, Suzuki, Y, Toda, S, Ito, I, Hattori, R, Matsukawa, Y, Gotoh, M, Takei, Y, Yuzawa, Y & Matsuo, S 2011, 'Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients', Nephrology Dialysis Transplantation, 巻. 26, 番号 7, pp. 2322-2332. https://doi.org/10.1093/ndt/gfq702

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. / Sawai, Akiho; Ito, Yasuhiko; Mizuno, Masashi; Suzuki, Yasuhiro; Toda, Susumu; Ito, Isao; Hattori, Ryohei; Matsukawa, Yoshihisa; Gotoh, Momokazu; Takei, Yoshifumi; Yuzawa, Yukio; Matsuo, Seiichi.

:: Nephrology Dialysis Transplantation, 巻 26, 番号 7, 01.07.2011, p. 2322-2332.

研究成果: Article

TY - JOUR

T1 - Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients

AU - Sawai, Akiho

AU - Ito, Yasuhiko

AU - Mizuno, Masashi

AU - Suzuki, Yasuhiro

AU - Toda, Susumu

AU - Ito, Isao

AU - Hattori, Ryohei

AU - Matsukawa, Yoshihisa

AU - Gotoh, Momokazu

AU - Takei, Yoshifumi

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Background. High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability.Methods. Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)-positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis.Results. Pre-dialysis uraemic peritoneum showed infiltration by CD68-positive macrophages, and mast cells, as compared with controls. Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). However, baseline peritoneal permeability was not correlated with infiltration by mast cells, B cells, T cells, neutrophils, serum C-reactive protein or other clinical factors. On multiple linear regression analysis, the number of CD68-positive macrophages in peritoneum was an independent predictor for baseline peritoneal permeability (P = 0.009).Conclusions. Peritoneal macrophage infiltration is predominant in uraemic patients and is an important factor in predicting baseline peritoneal permeability.

AB - Background. High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability.Methods. Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)-positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis.Results. Pre-dialysis uraemic peritoneum showed infiltration by CD68-positive macrophages, and mast cells, as compared with controls. Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). However, baseline peritoneal permeability was not correlated with infiltration by mast cells, B cells, T cells, neutrophils, serum C-reactive protein or other clinical factors. On multiple linear regression analysis, the number of CD68-positive macrophages in peritoneum was an independent predictor for baseline peritoneal permeability (P = 0.009).Conclusions. Peritoneal macrophage infiltration is predominant in uraemic patients and is an important factor in predicting baseline peritoneal permeability.

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U2 - 10.1093/ndt/gfq702

DO - 10.1093/ndt/gfq702

M3 - Article

VL - 26

SP - 2322

EP - 2332

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 7

ER -