Perspective of strategic plasma therapy in patients with epithelial ovarian cancer: A short review of plasma in cancer treatment

Hiroaki Kajiyama, Kae Nakamura, Fumi Utsumi, Hiromasa Tanaka, Masaru Hori, Fumitaka Kikkawa

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Epithelial ovarian cancer (EOC) is the leading cause of cancer-related death in women in Western countries. Once patients experience recurrence, complete cure is almost impossible. Nonequilibrium atmospheric pressure plasma (NEAPP) therapy has recently been focused on as a novel medical practice. We have elucidated the effect of nonequilibrium atmospheric pressure plasma on the growth of EOC, particularly in plasma-activated medium (PAM). In our recent report, we examined the role of reactive oxygen species (ROS) or their scavengers in chronic antineoplastic-resistant EOC cells. As a result, PAM exerted the antitumor effect of EOC cells in vitro and in vivo, even in chemoresistant cells. There are several problems under investigation, including intracellular mechanism of antitumor effect by PAM and adverse event in vivo. Through recent results about plasma in cancer treatment, PAM therapy is a promising treatment option for EOC and may contribute to a better patient prognosis in the future.

本文言語English
論文番号05FA05
ジャーナルJapanese Journal of Applied Physics
53
5 SPEC. ISSUE 1
DOI
出版ステータスPublished - 05-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)

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