Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population

Taro Kishi, Yasuhisa Fukuo, Reiji Yoshimura, Tomo Okochi, Tsuyoshi Kitajima, Hiroshi Naitoh, Wakako Umene-Nakano, Jun Nakamura, Norio Ozaki, Nakao Iwata

研究成果: Article

14 引用 (Scopus)

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Objective: Several investigations have suggested that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of major depressive disorder (MDD), and that 5-HT6 receptors might be a therapeutic target for serotonin selective reuptake inhibitor (SSRI) in MDD. To evaluate the association between HTR6 and the efficacy of SSRI treatment in Japanese MDD patients, we conducted a case-control study in a Japanese population sample. Methods: We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997), and performed an association analysis of HTR6 and the efficacy of SSRI treatment in 260 MDD patients. Results: We did not detect an association between tagging SNPs in HTR6 and the therapeutic response to SSRI inMDD in allele/genotype or haplotype analysis. Conclusions: HTR6 may not play an important role in the pathophysiology of SSRI response in the Japanese population. Because our sample was relatively small, statistical errors were possible in the results of our association analyses. To overcome these limitations, a replication study using a larger sample may be required for conclusive results.

元の言語English
ページ(範囲)481-486
ページ数6
ジャーナルHuman Psychopharmacology
25
発行部数6
DOI
出版物ステータスPublished - 01-08-2010

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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