Pharmacological prevention of peri-, and post-procedural myocardial injury in percutaneous coronary intervention

Hideki Ishiia, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

In recent years, percutaneous coronary intervention (PCI) has become a well-established technique for the treatment of coronary artery disease. PCI improves symptoms in patients with coronary artery disease and it has been increasing safety of procedures. However, peri- and post-procedural myocardial injury, including angiographical slow coronary flow, microvascular embolization, and elevated levels of cardiac enzyme, such as creatine kinase and troponin-T and -I, has also been reported even in elective cases. Furthermore, myocardial reperfusion injury at the beginning of myocardial reperfusion, which causes tissue damage and cardiac dysfunction, may occur in cases of acute coronary syndrome. Because patients with myocardial injury is related to larger myocardial infarction and have a worse long-term prognosis than those without myocardial injury, it is important to prevent myocardial injury during and/or after PCI in patients with coronary artery disease. To date, many studies have demonstrated that adjunctive pharmacological treatment suppresses myocardial injury and increases coronary blood flow during PCI procedures. In this review, we highlight the usefulness of pharmacological treatment in combination with PCI in attenuating myocardial injury in patients with coronary artery disease.

本文言語English
ページ(範囲)223-230
ページ数8
ジャーナルCurrent Cardiology Reviews
4
3
DOI
出版ステータスPublished - 09-10-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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