Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

Noriko Sugino, Tatsuo Ichinohe, Akifumi Takaori-Kondo, Taira Maekawa, Yasuo Miura

研究成果: ジャーナルへの寄稿総説査読

4 被引用数 (Scopus)

抄録

The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies.

本文言語英語
論文番号7
ジャーナルInflammation and Regeneration
37
1
DOI
出版ステータス出版済み - 03-04-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 免疫アレルギー学
  • 細胞生物学

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