TY - JOUR
T1 - Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line
AU - Miyake, Seiji
AU - Kobayashi, Saori
AU - Tsubota, Kazuo
AU - Ozawa, Yoko
PY - 2014/4/4
Y1 - 2014/4/4
N2 - The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina.
AB - The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina.
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U2 - 10.1016/j.bbrc.2014.02.135
DO - 10.1016/j.bbrc.2014.02.135
M3 - Article
C2 - 24613837
AN - SCOPUS:84897972600
SN - 0006-291X
VL - 446
SP - 535
EP - 540
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -