Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, Toshitaka Nabeshima

研究成果: Article

抄録

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

元の言語English
ページ(範囲)97-103
ページ数7
ジャーナルResearch Communications in Alcohol and Substances of Abuse
16
発行部数3
出版物ステータスPublished - 01-12-1995
外部発表Yes

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sigma Receptors
Phencyclidine
Parietal Lobe
Acetylcholine
Rats
Microdialysis
Brain
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology

これを引用

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abstract = "The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.",
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Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors. / Ohzeki, M.; Hasegawa, M.; Katoh, T.; Yamada, K.; Hasegawa, T.; Furukawa, H.; Nabeshima, Toshitaka.

:: Research Communications in Alcohol and Substances of Abuse, 巻 16, 番号 3, 01.12.1995, p. 97-103.

研究成果: Article

TY - JOUR

T1 - Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

AU - Ohzeki, M.

AU - Hasegawa, M.

AU - Katoh, T.

AU - Yamada, K.

AU - Hasegawa, T.

AU - Furukawa, H.

AU - Nabeshima, Toshitaka

PY - 1995/12/1

Y1 - 1995/12/1

N2 - The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

AB - The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

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