Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki; M. Hasegawa; T. Katoh; K. Yamada; T. Hasegawa; H. Furukawa; Toshitaka Nabeshima

Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, Toshitaka Nabeshima

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

本文言語	英語
ページ（範囲）	97-103
ページ数	7
ジャーナル	Research Communications in Alcohol and Substances of Abuse
巻	16
号	3
出版ステータス	出版済み - 1995
外部発表	はい

All Science Journal Classification (ASJC) codes

医学（その他）
毒物学

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abstract = "The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.",

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T1 - Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

AU - Ohzeki, M.

AU - Hasegawa, M.

AU - Katoh, T.

AU - Yamada, K.

AU - Hasegawa, T.

AU - Furukawa, H.

AU - Nabeshima, Toshitaka

PY - 1995

Y1 - 1995

N2 - The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

AB - The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

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ER -

Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

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