Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, Toshitaka Nabeshima

研究成果: Article

抜粋

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

元の言語English
ページ(範囲)97-103
ページ数7
ジャーナルResearch Communications in Alcohol and Substances of Abuse
16
発行部数3
出版物ステータスPublished - 01-12-1995
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology

これを引用

Ohzeki, M., Hasegawa, M., Katoh, T., Yamada, K., Hasegawa, T., Furukawa, H., & Nabeshima, T. (1995). Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors. Research Communications in Alcohol and Substances of Abuse, 16(3), 97-103.