Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, T. Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

抄録

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

本文言語英語
ページ(範囲)97-103
ページ数7
ジャーナルResearch Communications in Alcohol and Substances of Abuse
16
3
出版ステータス出版済み - 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 毒物学

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