Phencyclidine-induced retrograde amnesia in mice

Toshitaka Nabeshima, Teruo Kozawa, Hiroshi Furukawa, Tsutomu Kameyama

研究成果: Article

24 引用 (Scopus)

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The amnesic action of phencyclidine (PCP) was investigated in mice using a passive avoidance- and escape-learning method. PCP (10-30 mg/kg) administered immediately after the training test dose-dependently shortened and prolonged the step-down latency and escape latency, respectively in the retention test. There was a significant inverse relationship between the step-down and escape latencies, indicating that PCP had induced amnesia. The amnesic actions of PCP were retrograde, being observed when mice were given PCP within 10 min but not more than 30 min after the training test. The amnesic effects of PCP on both variables were antagonized significantly by physostigmine and naloxone, whereas cyproheptadine and haloperidol had no effect. None of these drugs by themselves affected passive avoidance- or escape-learning performance. These results suggest that the retrograde amnesic actions of PCP were produced via either the cholinergic or the opioidergic systems or both, but not through the serotonergic and the dopaminergic systems.

元の言語English
ページ(範囲)334-337
ページ数4
ジャーナルPsychopharmacology
89
発行部数3
DOI
出版物ステータスPublished - 01-07-1986
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Pharmacology

フィンガープリント Phencyclidine-induced retrograde amnesia in mice' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Nabeshima, T., Kozawa, T., Furukawa, H., & Kameyama, T. (1986). Phencyclidine-induced retrograde amnesia in mice. Psychopharmacology, 89(3), 334-337. https://doi.org/10.1007/BF00174370