抄録
All the components of phencyclidine(PCP)-induced stereotyped behaviors, including sniffing, backpedalling, turning and head weaving were significantly decreased in rats following kainic acid lesion of the striatum. In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. These results suggest that not only dopaminergic but also serotonergic and other systems in the striatum may play important roles in PCP-induced stereotyped behaviors.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 229-234 |
| ページ数 | 6 |
| ジャーナル | European Journal of Pharmacology |
| 巻 | 93 |
| 発行部数 | 3-4 |
| DOI | |
| 出版物ステータス | Published - 30-09-1983 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum. / Nabeshima, Toshitaka; Yamaguchi, Kazumasa; Yamada, Kiyofumi; Hiramatsu, Masayuki; Furukawa, Hiroshi; Kameyama, Tsutomu.
：: European Journal of Pharmacology, 巻 93, 番号 3-4, 30.09.1983, p. 229-234.研究成果: Article
TY - JOUR
T1 - Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum
AU - Nabeshima, Toshitaka
AU - Yamaguchi, Kazumasa
AU - Yamada, Kiyofumi
AU - Hiramatsu, Masayuki
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
PY - 1983/9/30
Y1 - 1983/9/30
N2 - All the components of phencyclidine(PCP)-induced stereotyped behaviors, including sniffing, backpedalling, turning and head weaving were significantly decreased in rats following kainic acid lesion of the striatum. In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. These results suggest that not only dopaminergic but also serotonergic and other systems in the striatum may play important roles in PCP-induced stereotyped behaviors.
AB - All the components of phencyclidine(PCP)-induced stereotyped behaviors, including sniffing, backpedalling, turning and head weaving were significantly decreased in rats following kainic acid lesion of the striatum. In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. These results suggest that not only dopaminergic but also serotonergic and other systems in the striatum may play important roles in PCP-induced stereotyped behaviors.
UR - http://www.scopus.com/inward/record.url?scp=0020551181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020551181&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(83)90142-5
DO - 10.1016/0014-2999(83)90142-5
M3 - Article
C2 - 6416871
AN - SCOPUS:0020551181
VL - 93
SP - 229
EP - 234
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3-4
ER -