Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum

Toshitaka Nabeshima, Kazumasa Yamaguchi, Kiyofumi Yamada, Masayuki Hiramatsu, Hiroshi Furukawa, Tsutomu Kameyama

研究成果: Article

41 引用 (Scopus)

抄録

All the components of phencyclidine(PCP)-induced stereotyped behaviors, including sniffing, backpedalling, turning and head weaving were significantly decreased in rats following kainic acid lesion of the striatum. In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. These results suggest that not only dopaminergic but also serotonergic and other systems in the striatum may play important roles in PCP-induced stereotyped behaviors.

元の言語English
ページ(範囲)229-234
ページ数6
ジャーナルEuropean Journal of Pharmacology
93
発行部数3-4
DOI
出版物ステータスPublished - 30-09-1983
外部発表Yes

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Stereotyped Behavior
Phencyclidine
Neurotoxins
5,6-Dihydroxytryptamine
Head
Kainic Acid
Oxidopamine

All Science Journal Classification (ASJC) codes

  • Pharmacology

これを引用

Nabeshima, Toshitaka ; Yamaguchi, Kazumasa ; Yamada, Kiyofumi ; Hiramatsu, Masayuki ; Furukawa, Hiroshi ; Kameyama, Tsutomu. / Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum. :: European Journal of Pharmacology. 1983 ; 巻 93, 番号 3-4. pp. 229-234.
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Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum. / Nabeshima, Toshitaka; Yamaguchi, Kazumasa; Yamada, Kiyofumi; Hiramatsu, Masayuki; Furukawa, Hiroshi; Kameyama, Tsutomu.

:: European Journal of Pharmacology, 巻 93, 番号 3-4, 30.09.1983, p. 229-234.

研究成果: Article

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