TY - JOUR
T1 - Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors
AU - Karasawa, Nobuyuki
AU - Arai, Ryohachi
AU - Isomura, Genzoh
AU - Yamada, Keiki
AU - Sakai, Kazuyoshi
AU - Sakai, Masao
AU - Nagatsu, Toshiharu
AU - Nagatsu, Ikuko
N1 - Funding Information:
This work was supported by Grants-in-Aid for Specially Promoted Research (to T. Nagatsu), Grant-in-Aid for Scientific Research on Priority Areas (to I. Nagatsu), a grant (to I. Nagatsu) from the Ministry of Education, Science and Culture, Japan, a grant (to I. Nagatsu) from the Ministry of Welfare and Health of Japan and by a Grant-in-Aid from Fujita Health University, Japan.
PY - 1994/9/26
Y1 - 1994/9/26
N2 - After 5-hydroxy-l-tryptophan (5-HTP) and l-3,4-dihydroxyphenylalanine (l-DOPA) were injected i.p. in the laboratory shrew Suncus murinus, immunocytochemical and immunofluorescence studies were conducted on continuous or same sections of the brain, using specific anti-tyrosine hydroxylase (TH), anti-aromatic l-amino acid decarboxylase (AADC), anti-dopamine (DA) and anti-serotonin (5-HT) antisera which were produced in our laboratory. The results of double-staining by the immunofluorescence method as well as immunoelectron microscopy strongly indicate that the cells of the premammillary nucleus of the laboratory shrew brain (AADC-only-positive neurons) are capable of synthesizing DA and 5-HT simultaneously upon simultaneous administration of l-DOPA and 5-HTP.
AB - After 5-hydroxy-l-tryptophan (5-HTP) and l-3,4-dihydroxyphenylalanine (l-DOPA) were injected i.p. in the laboratory shrew Suncus murinus, immunocytochemical and immunofluorescence studies were conducted on continuous or same sections of the brain, using specific anti-tyrosine hydroxylase (TH), anti-aromatic l-amino acid decarboxylase (AADC), anti-dopamine (DA) and anti-serotonin (5-HT) antisera which were produced in our laboratory. The results of double-staining by the immunofluorescence method as well as immunoelectron microscopy strongly indicate that the cells of the premammillary nucleus of the laboratory shrew brain (AADC-only-positive neurons) are capable of synthesizing DA and 5-HT simultaneously upon simultaneous administration of l-DOPA and 5-HTP.
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U2 - 10.1016/0304-3940(94)90936-9
DO - 10.1016/0304-3940(94)90936-9
M3 - Article
C2 - 7845627
AN - SCOPUS:0028031252
SN - 0304-3940
VL - 179
SP - 65
EP - 70
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -