Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors

Nobuyuki Karasawa, Ryohachi Arai, Genzoh Isomura, Keiki Yamada, Kazuyoshi Sakai, Masao Sakai, Toshiharu Nagatsu, Ikuko Nagatsu

研究成果: ジャーナルへの寄稿学術論文査読

28 被引用数 (Scopus)

抄録

After 5-hydroxy-l-tryptophan (5-HTP) and l-3,4-dihydroxyphenylalanine (l-DOPA) were injected i.p. in the laboratory shrew Suncus murinus, immunocytochemical and immunofluorescence studies were conducted on continuous or same sections of the brain, using specific anti-tyrosine hydroxylase (TH), anti-aromatic l-amino acid decarboxylase (AADC), anti-dopamine (DA) and anti-serotonin (5-HT) antisera which were produced in our laboratory. The results of double-staining by the immunofluorescence method as well as immunoelectron microscopy strongly indicate that the cells of the premammillary nucleus of the laboratory shrew brain (AADC-only-positive neurons) are capable of synthesizing DA and 5-HT simultaneously upon simultaneous administration of l-DOPA and 5-HTP.

本文言語英語
ページ(範囲)65-70
ページ数6
ジャーナルNeuroscience Letters
179
1-2
DOI
出版ステータス出版済み - 26-09-1994

All Science Journal Classification (ASJC) codes

  • 神経科学一般

フィンガープリント

「Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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