Phosphorylation of smg p21B/rap1B p21 by cyclic GMP-dependent protein kinase

Yasushi Miura, Kozo Kaibuchi, Takahito Itoh, Jackie D. Corbin, Sharron H. Francis, Yoshimi Takai

研究成果: Article査読

27 被引用数 (Scopus)

抄録

smg p21B/rap1B p21, a member of ras p21-like small GTP-binding protein superfamily, has been shown to be phosphorylated by cyclic AMP-dependent protein kinase (protein kinase A). We show here that this protein was also phosphorylated by cyclic GMP-dependent protein kinase (protein kinase G) in a cell-free system. The same serine residue (Ser179) in the C-terminal region was phosphorylated by both protein kinases G and A. The Km and Vmax values of smg p21B for protein kinase G were 5 × 10-7 M and 4 × 10-9 mol/min/mg, and those values for protein kinase A were 1 × 10-7 M and 3 × 10-8 mol/min/mg.

本文言語English
ページ(範囲)171-174
ページ数4
ジャーナルFEBS Letters
297
1-2
DOI
出版ステータスPublished - 03-02-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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