抄録
The AML1 -CBFβ transcription factor complex Is the most frequent target of specific chromosome translocations in acute myeloid leukemia (AML). The promyelocytic leukemia (PML) gene is also frequently involved in AML-associated translocation. Here we report that a specific isoform PMLI forms a complex with AML1. PMLI was able to recruit AML1 and coactivator p300 in PML nuclear bodies and enhance the AML1-mediated transcription in the presence of p300. A specific C-terminal region of PML I and a C-terminal region of AML1 were found to be required for both their association and colocalization in the nuclear bodies. Overexpression of PML I stimulates myeloid cells to differentiate. These results suggest that PML I could act as a mediator for AML1 and its coactivator p300/CBP to assemble into functional complexes and, consequently, activate AML1-dependent transcription and myeloid cell differentiation.
本文言語 | 英語 |
---|---|
ページ(範囲) | 292-300 |
ページ数 | 9 |
ジャーナル | Blood |
巻 | 105 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 01-01-2005 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 生化学
- 免疫学
- 血液学
- 細胞生物学