Physical and functional link of the leukemia-associated factors AML1 and PML

Lan Anh Nguyen, Pier Paolo Pandolfi, Yukiko Aikawa, Yusuke Tagata, Misao Ohki, Issay Kitabayashi

研究成果: ジャーナルへの寄稿学術論文査読

36 被引用数 (Scopus)

抄録

The AML1 -CBFβ transcription factor complex Is the most frequent target of specific chromosome translocations in acute myeloid leukemia (AML). The promyelocytic leukemia (PML) gene is also frequently involved in AML-associated translocation. Here we report that a specific isoform PMLI forms a complex with AML1. PMLI was able to recruit AML1 and coactivator p300 in PML nuclear bodies and enhance the AML1-mediated transcription in the presence of p300. A specific C-terminal region of PML I and a C-terminal region of AML1 were found to be required for both their association and colocalization in the nuclear bodies. Overexpression of PML I stimulates myeloid cells to differentiate. These results suggest that PML I could act as a mediator for AML1 and its coactivator p300/CBP to assemble into functional complexes and, consequently, activate AML1-dependent transcription and myeloid cell differentiation.

本文言語英語
ページ(範囲)292-300
ページ数9
ジャーナルBlood
105
1
DOI
出版ステータス出版済み - 01-01-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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