Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren

Chie Fujii, Hisataka Sakakibara, Takaaki Kondo, Hiroshi Yatsuya, Koji Tamakoshi, Hideaki Toyoshima

研究成果: Article

11 引用 (Scopus)

抄録

Background: Plasma fibrinogen level has been recognized as an independent risk factor for atherosclerosis and its thrombotic complications in adults. The present study aimed to clarify the association between plasma fibrinogen levels and cardiovascular risk factors in Japanese children. Methods: A total of 294 schoolchildren (145 boys and 149 girls) aged 10-13 years in a town in Nagano Prefecture, Japan, were surveyed in 2000 for body mass index (BMI), plasma fibrinogen, serum C-reactive protein (CRP), serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, hemoglobin (Hb) A1c, and ratio of serum total cholesterol to serum HDL cholesterol (TCHR). Results: The mean value and standard deviation of plasma fibrinogen level among the schoolchildren was 226.0±39.7 mg/dL for boys and 245.3 ± 40.9 mg/dL for girls; significantly higher for girls. Among plasma fibrinogen tertiles, serum CRP tended to increase with plasma fibrinogen in both boys and girls. An increasing trend was also found in serum total cholesterol in boys, and in TCHR, HbA1c and BMI in girls. Multiple linear regression analysis revealed significant associations of plasma fibrinogen with serum CRP and HbA1c in both sexes, with TCHR in boys, and with BMI in girls. Conclusions: Plasma fibrinogen levels were associated with cardiovascular risk factors such as serum CRP, TCHR, HbA1c, and BMI in Japanese schoolchildren.

元の言語English
ページ(範囲)64-70
ページ数7
ジャーナルJournal of Epidemiology
16
発行部数2
DOI
出版物ステータスPublished - 14-03-2006
外部発表Yes

Fingerprint

Fibrinogen
C-Reactive Protein
Blood Proteins
Body Mass Index
Serum
Cholesterol
HDL Cholesterol
Linear Models
Atherosclerosis
Japan
Hemoglobins
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Fujii, Chie ; Sakakibara, Hisataka ; Kondo, Takaaki ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Toyoshima, Hideaki. / Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. :: Journal of Epidemiology. 2006 ; 巻 16, 番号 2. pp. 64-70.
@article{7d232e42d4d14b69ba7f0df43eda6998,
title = "Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren",
abstract = "Background: Plasma fibrinogen level has been recognized as an independent risk factor for atherosclerosis and its thrombotic complications in adults. The present study aimed to clarify the association between plasma fibrinogen levels and cardiovascular risk factors in Japanese children. Methods: A total of 294 schoolchildren (145 boys and 149 girls) aged 10-13 years in a town in Nagano Prefecture, Japan, were surveyed in 2000 for body mass index (BMI), plasma fibrinogen, serum C-reactive protein (CRP), serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, hemoglobin (Hb) A1c, and ratio of serum total cholesterol to serum HDL cholesterol (TCHR). Results: The mean value and standard deviation of plasma fibrinogen level among the schoolchildren was 226.0±39.7 mg/dL for boys and 245.3 ± 40.9 mg/dL for girls; significantly higher for girls. Among plasma fibrinogen tertiles, serum CRP tended to increase with plasma fibrinogen in both boys and girls. An increasing trend was also found in serum total cholesterol in boys, and in TCHR, HbA1c and BMI in girls. Multiple linear regression analysis revealed significant associations of plasma fibrinogen with serum CRP and HbA1c in both sexes, with TCHR in boys, and with BMI in girls. Conclusions: Plasma fibrinogen levels were associated with cardiovascular risk factors such as serum CRP, TCHR, HbA1c, and BMI in Japanese schoolchildren.",
author = "Chie Fujii and Hisataka Sakakibara and Takaaki Kondo and Hiroshi Yatsuya and Koji Tamakoshi and Hideaki Toyoshima",
year = "2006",
month = "3",
day = "14",
doi = "10.2188/jea.16.64",
language = "English",
volume = "16",
pages = "64--70",
journal = "Journal of Epidemiology",
issn = "0917-5040",
publisher = "Japan Epidemiology Association",
number = "2",

}

Fujii, C, Sakakibara, H, Kondo, T, Yatsuya, H, Tamakoshi, K & Toyoshima, H 2006, 'Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren', Journal of Epidemiology, 巻. 16, 番号 2, pp. 64-70. https://doi.org/10.2188/jea.16.64

Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. / Fujii, Chie; Sakakibara, Hisataka; Kondo, Takaaki; Yatsuya, Hiroshi; Tamakoshi, Koji; Toyoshima, Hideaki.

:: Journal of Epidemiology, 巻 16, 番号 2, 14.03.2006, p. 64-70.

研究成果: Article

TY - JOUR

T1 - Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren

AU - Fujii, Chie

AU - Sakakibara, Hisataka

AU - Kondo, Takaaki

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Toyoshima, Hideaki

PY - 2006/3/14

Y1 - 2006/3/14

N2 - Background: Plasma fibrinogen level has been recognized as an independent risk factor for atherosclerosis and its thrombotic complications in adults. The present study aimed to clarify the association between plasma fibrinogen levels and cardiovascular risk factors in Japanese children. Methods: A total of 294 schoolchildren (145 boys and 149 girls) aged 10-13 years in a town in Nagano Prefecture, Japan, were surveyed in 2000 for body mass index (BMI), plasma fibrinogen, serum C-reactive protein (CRP), serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, hemoglobin (Hb) A1c, and ratio of serum total cholesterol to serum HDL cholesterol (TCHR). Results: The mean value and standard deviation of plasma fibrinogen level among the schoolchildren was 226.0±39.7 mg/dL for boys and 245.3 ± 40.9 mg/dL for girls; significantly higher for girls. Among plasma fibrinogen tertiles, serum CRP tended to increase with plasma fibrinogen in both boys and girls. An increasing trend was also found in serum total cholesterol in boys, and in TCHR, HbA1c and BMI in girls. Multiple linear regression analysis revealed significant associations of plasma fibrinogen with serum CRP and HbA1c in both sexes, with TCHR in boys, and with BMI in girls. Conclusions: Plasma fibrinogen levels were associated with cardiovascular risk factors such as serum CRP, TCHR, HbA1c, and BMI in Japanese schoolchildren.

AB - Background: Plasma fibrinogen level has been recognized as an independent risk factor for atherosclerosis and its thrombotic complications in adults. The present study aimed to clarify the association between plasma fibrinogen levels and cardiovascular risk factors in Japanese children. Methods: A total of 294 schoolchildren (145 boys and 149 girls) aged 10-13 years in a town in Nagano Prefecture, Japan, were surveyed in 2000 for body mass index (BMI), plasma fibrinogen, serum C-reactive protein (CRP), serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, hemoglobin (Hb) A1c, and ratio of serum total cholesterol to serum HDL cholesterol (TCHR). Results: The mean value and standard deviation of plasma fibrinogen level among the schoolchildren was 226.0±39.7 mg/dL for boys and 245.3 ± 40.9 mg/dL for girls; significantly higher for girls. Among plasma fibrinogen tertiles, serum CRP tended to increase with plasma fibrinogen in both boys and girls. An increasing trend was also found in serum total cholesterol in boys, and in TCHR, HbA1c and BMI in girls. Multiple linear regression analysis revealed significant associations of plasma fibrinogen with serum CRP and HbA1c in both sexes, with TCHR in boys, and with BMI in girls. Conclusions: Plasma fibrinogen levels were associated with cardiovascular risk factors such as serum CRP, TCHR, HbA1c, and BMI in Japanese schoolchildren.

UR - http://www.scopus.com/inward/record.url?scp=33645037100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645037100&partnerID=8YFLogxK

U2 - 10.2188/jea.16.64

DO - 10.2188/jea.16.64

M3 - Article

VL - 16

SP - 64

EP - 70

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 2

ER -