TY - JOUR
T1 - Polymorphism in the second intron of dopamine receptor D4 gene in humans and apes
AU - Shimada, Makoto K.
AU - Inoue-Murayama, Miho
AU - Ueda, Yuko
AU - Maejima, Masami
AU - Murayama, Yuichi
AU - Takenaka, Osamu
AU - Hayasaka, Ikuo
AU - Ito, Shin'ichi
N1 - Funding Information:
We thank Professor Yasuo Bunai and Dr. Atsushi Nagai, Gifu University School of Medicine, for donating genomic DNA of Hungarian Caucasians and for their excellent advice. This work was supported in part by the Cooperation Research Program of the Primate Research Institute, Kyoto University, and the Bio-oriented Technology Research Advancement Institution (BRAIN), Japan.
PY - 2004/4/16
Y1 - 2004/4/16
N2 - The dopamine receptor D4 (DRD4) has received increasing research attention in behavioral science, psychiatry, and psychopharmacology. However, the number of available genetic markers for primates is still insufficient. We identified a novel variation/polymorphism in the second intron of DRD4 in humans based on the survey of 210 Japanese: a 6bp insertion (allele frequency: 0.002) and 8bp deletion (0.024); however, 94 Hungarian Caucasians were found to be monomorphic. Polymorphisms of the homologous region were also found in a survey of 93 specimens from four species of great apes and 51 specimens from seven species of gibbons. The polymorphisms consist of both single nucleotide substitutions and variations in the number of tandem duplications of short GC-rich sequences. Because of usefulness of primates in behavioral science, this polymorphism may be a useful marker for association studies with behavioral traits in both humans and apes.
AB - The dopamine receptor D4 (DRD4) has received increasing research attention in behavioral science, psychiatry, and psychopharmacology. However, the number of available genetic markers for primates is still insufficient. We identified a novel variation/polymorphism in the second intron of DRD4 in humans based on the survey of 210 Japanese: a 6bp insertion (allele frequency: 0.002) and 8bp deletion (0.024); however, 94 Hungarian Caucasians were found to be monomorphic. Polymorphisms of the homologous region were also found in a survey of 93 specimens from four species of great apes and 51 specimens from seven species of gibbons. The polymorphisms consist of both single nucleotide substitutions and variations in the number of tandem duplications of short GC-rich sequences. Because of usefulness of primates in behavioral science, this polymorphism may be a useful marker for association studies with behavioral traits in both humans and apes.
UR - https://www.scopus.com/pages/publications/1642355149
UR - https://www.scopus.com/pages/publications/1642355149#tab=citedBy
U2 - 10.1016/j.bbrc.2004.03.006
DO - 10.1016/j.bbrc.2004.03.006
M3 - Article
C2 - 15044110
AN - SCOPUS:1642355149
SN - 0006-291X
VL - 316
SP - 1186
EP - 1190
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -