Polymorphisms of two Fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody

Yuzuru Ikehara, Hisanori Yasutomi, Tabito Kitamura, Nobuyuki Shimizu, Ken ichi Inada, Masae Tatematsu, Keitaro Matsuo, Hisashi Narimatsu, Yasuhiro Kodera, Yoshitaka Yamamura, Shoko Nishihara, Nobuyuki Hamajima

研究成果: Article査読

87 被引用数 (Scopus)

抄録

Helicobacter pylori attach to the gastric mucosa with adhesin, which binds to Lewis b (Leb) or H type I carbohydrate structures. The Secretor (Se) gene and Lewis (Le) gene are involved in type I Le antigen synthesis. The present study was performed to investigate the possibility that Se and Le gene polymorphisms alter the risk of H. Pylori infection. Two hundred thirty-nine participants were genotyped for Se and Le and tested for the presence of anti-H. pylori IgG antibodies. Using the normal gastric mucosa from 60 gastric cancer patients, we assessed immunohistochemically whether type I Le antigen expression depended on the Se and Le genotypes. The H. pylori infection rate was positively associated with the number of Se alleles (se/se group, 45.1%; Se/se group, 64.6%; and Se/Se group, 73.3%) and negatively associated with the number of Le alleles (le/le group, 76.4%; Le/le group, 68.3%; and Le/Le group, 55.6%). When the subjects were classified into three groups [low risk, (se/se, Le/Le) genotype; high risk, (Se/Se, le/le), (Se/Se, Le/le), and (Se/se, le/le) genotypes; moderate risk, other than low- or high-risk group], the odds ratio relative to the low-risk group was 3.30 (95% confidence interval, 1.40-7.78) for the moderate-risk group and 10.33 (95% confidence interval, 3.16-33.8) for the high-risk group. Immunohistochemical analysis supported the finding that Se and Le genotypes affected the expression of H. pylori adhesin ligands. We conclude that Se and Le genotypes affect susceptibility to H. pylori infection.

本文言語English
ページ(範囲)971-977
ページ数7
ジャーナルCancer Epidemiology Biomarkers and Prevention
10
9
出版ステータスPublished - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

フィンガープリント 「Polymorphisms of two Fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル