Possible involvement of protein kinase C in interleukin-1 production by mouse peritoneal macrophages

Yuko Katakami, Yoshinobu Nakao, Toshimitsu Matsui, Tamio Koizumi, Kozo Kaibuchi, Yoshimi Takai, Takuo Fujita

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Both lipopolysaccharide (LPS) and phorbol-12,13-dibutyrate (PDBu), a protein kinase C-activating phorbol ester, induced interleukin-1 (IL-1) production in mouse peritoneal macrophages. Prolonged treatment of the cells with PDBu led to the down-regulation and complete disappearance of protein kinase C. In these cells, PDBu did not increase IL-1 production, but LPS still stimulated IL-1 production although the maximum level was slightly reduced. These results suggest that protein kinase C and another unknown signal pathway are involved in LPS-induced IL-1 production.

本文言語English
ページ(範囲)355-362
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
135
2
DOI
出版ステータスPublished - 13-03-1986
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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